Visible-light-initiated regio- & stereoselective C(sp²)–H phosphorylation of enamides under transition-metal-free conditions

Ji-Yu Tao,^†a Qing-Hong Zhang,^†a Tong-Hao Zhu,^†a,d Xin-Wen Xu,^†a Kun Ni,^a Qiao Zhao,^a Zheng-Bao Qin,^a Yu Zhang,^b Lili Zhao,^a and Kai Zhao^*a,c

^aInstitute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University, Nanjing 211816, China. E-mail: ias_kzhao@njtech.edu.cn

^bCollege of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China

^cGuangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology, Shenzhen 518055, China

^dInstitute of Advanced Studies, Taizhou University, 1139 Shifu Avenue, Taizhou 318000, China

Abstract: A visible-light-induced stereo- and regioselective phosphorylation reaction of enamides with phosphine oxides has been disclosed, delivering synthetically and pharmaceutically appealing β-phosphorylated enamides with broad substrate scopes and excellent functional group tolerance under transition-metal-free conditions.

Org. Chem. Front., 2022, 9, 6540−6546. (2021年影响因子: 5.456).

论文链接：https://doi.org/10.1039/D2QO01304E