HP(O)Ph₂/H₂O-Promoted Hydrodefluorination of Trifluoromethyl Alkenes

Xue-Qiang Chu,*^a Li-Wen Sun,^a Yu-Lan Chen,^a Jia-Wei Chen,^a Xuan Ying,^a Mengtao Ma,^b Zhi-Liang Shen*^a

^a Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China.

^b Department of Chemistry and Materials Science, College of Science, Nanjing Forestry University, Nanjing 210037, China.

Abstract: An efficient transition-metal-free hydrodefluorination of trifluoromethyl alkenes for accessing gem-difluoroalkenes is developed. It was surprising to find that phosphoryl anion is able to mediate the defluorination. The successful realization of the reaction could also be attributed to the utility of water as an eco-friendly promoter.

Green Chem. 2022, DOI: 10.1039/D1GC04645D. (Impact factor: 10.182)

论文链接：https://pubs.rsc.org/en/Content/ArticleLanding/2022/GC/D1GC04645D